HSP27: Family Members

The human genome encodes 10 members of the HSPB family (Table 2).³⁸ These proteins have molecular mass in the range of 17.0–28.4 kDa and contain a conservative α-crystallin domain. Some of these proteins (HSPB1, HSPB5, HSPB6, HSPB8) are ubiquitously expressed in practically all cell types, whereas others (HSPB3, HSPB4, HSPB7, HSPB9, and HSPB10) are less abundantly expressed and their level is high only in certain tissues^39,40. Thus, all members of HSPB family are important for cell functioning under normal and stress conditions.

 

Table 2. Members of the HspB family

Name	Synonyms	Uniprot ID	Chromosome Location	Number of amino acid residues
HspB1	Hsp25, Hsp27,Hsp28	P04792	7q11.23	205
HspB2	MKBP	Q16082	11q22-q23	182
HspB3	HSP27, HSPL27	Q12988	5q11.2	150
HspB4	αA-Crystallin	P02489	21q22.3	173
HspB5	βB-Crystallin	P02511	11q22.3-q23.1	175
HspB6	Hsp20, p20	O14558	19q13.12	157
HspB7	cvHsp	Q9UBY9	1p36.23-p34.3	170
HspB8	Hsp22, H11	Q9UJY1	12q24.23	196
HspB9		Q9BQS6	17q21.2	159
HspB10	ODF1	Q14990	8q22.3	250