HSP27: Localization

ICC staining of Hsp27 (green) in mouse spinal cord sections (DAPI merged with Alexa 488) using Anti-Hsp27 (clone: 5D12-A12)
Hsp27 is a very ubiquitous Small Heat Shock Protein and is present in all human tissues. Particularly, they are abundantly expressed in skeletal, cardiac and smooth muscles36. In the cells, they are found in the cytosol of cells18; membrane bound37  secreted6  and/or associated with intracellular organelles like the mitochondria and the cytoskeleton38  as well as translocated to the nucleus.