HSP27: Tables

Table 1. Human and mouse orthologs of Hsp27 (HspB1).

	Human	Mouse
Entrez Gene	3315	15507
Ensembl	ENSG00000106211	ENSMUSG00000004951
UniProt	P04792	P14602
Reference sequence (mRNA)	NM_001540	NM_013560.2
Reference sequence protein	NP_001531.1	NP_038588.2
Gene locus	chr7:75,931,875-75,933,614	chr5:135,887,919-135,889,563

 

Table 2. Members of the HspB family

Name	Synonyms	Uniprot ID	Chromosome Location	Number of amino acid residues
HspB1	Hsp25, Hsp27,Hsp28	P04792	7q11.23	205
HspB2	MKBP	Q16082	11q22-q23	182
HspB3	HSP27, HSPL27	Q12988	5q11.2	150
HspB4	αA-Crystallin	P02489	21q22.3	173
HspB5	βB-Crystallin	P02511	11q22.3-q23.1	175
HspB6	Hsp20, p20	O14558	19q13.12	157
HspB7	cvHsp	Q9UBY9	1p36.23-p34.3	170
HspB8	Hsp22, H11	Q9UJY1	12q24.23	196
HspB9		Q9BQS6	17q21.2	159
HspB10	ODF1	Q14990	8q22.3	250

 

Table 3. The congenital diseases due to mutations of the human HSPB family of proteins

Name	Tissue Distribution	Disease
HspB1	Ubiquitous	Charcot-Marie-Tooth disease type 2, distal hereditary motor neuropathy
HspB2	Cardiac and skeletal muscle	Myotonic dystrophy, different forms neuropathology
HspB3	Cardiac and Skeletal muscle	Motor neuropathy
HspB4	Eye lens	Cataract
HspB5	Ubiquitous	Cataract
HspB6	Ubiquitous	Dilated cardiomyopathy
HspB8	Ubiquitous	Charcot-Marie-Tooth disease type 2, distal hereditary motor neuropathy
HspB9	Testis	Upregulated in certain tumors